When I read about Relistor I finally felt hope in my long struggle with constipation. For years my life has revolved around NOT being able to have a bowel movement due to my pain medication. I have taken 2 12mg doses in the last 2 days with No result. All my hope is fading. Has anyone had to give this medication time and multiple doses before they see results, or has it always been immediate (within 24 hr's) that will determine if this medication will work for you?