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What is relationship between lisinopril and non steroidal anti iflammatory drugs?

Responses (2)

mahammed 16 Mar 2012

the NSAID is reduse the antihyptensive effect of lisinopril .beacuse it is blocking bradykinin-mediated vasodilation,
which is at least in part, prostaglandin mediated.in which activated by inhibtion of kinase1.

LaurieShay 17 Mar 2012

The literature points out the following:

Patients receiving ACE inhibitors who require prolonged (greater than 1 week) concomitant therapy with an NSAID should have blood pressure monitored more closely following initiation, discontinuation, or change of dosage of the NSAID. Renal function should also be evaluated periodically during prolonged coadministration. The interaction is not expected to occur with low doses (e.g., low-dose aspirin) or intermittent short-term administration of NSAIDs.

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