Invokana (canagliflozin) is an oral diabetes medicine that helps control blood sugar levels. It works by helping the kidneys get rid of glucose from your bloodstream.
The recommended dose is 100 to 300mg once daily, taken before the first meal of the day.
Actos (Pioglitazone) is a drug that reduces the amount of glucose in the blood. Actos should be taken once daily and can be taken without regard to meals.
For ease of compliance it would be easier to take them together at the same time before the first meal of the day but you should check with your doctor first.
You may get better control if you take them 12 hours apart and reduce your risk of hypoglycemia.
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