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Recommended adult Dosage for Cefazolin?

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Anonymous 8 Apr 2011

Hello,

Cefazolin Dosing Information

Usual Adult Dose for Bacterial Endocarditis Prophylaxis:

As an alternative to parenteral ampicillin: 1 g IV or IM 30 minutes before the scheduled procedure
An additional dose is recommended if the procedure lasts longer than 2 hours.

Usual Adult Dose for Cholecystitis:

1 to 2 g IV every 6 to 8 hours for 14 days
Maximum dose: 12 g/day
The use of antibiotics to treat cholecystitis is debatable. Surgical consultation should be considered.

Usual Adult Dose for Endocarditis:

Native valve infections due to staphylococci in penicillin-allergic (non-anaphylactoid type) patients: 2 g IV every 8 hours with or without gentamicin 3 mg/kg/day IV or IM in 2 or 3 divided doses
Duration: Cefazolin, 6 weeks; gentamicin, 3 to 5 days

Usual Adult Dose for Joint Infection:

1 to 2 g IV every 6 to 8 hours
Maximum dose: 12 g/day
Duration: 3 to 4 weeks. Longer therapy, 6 weeks or more, may be required for prosthetic joint infections. In addition, removal of the involved prosthesis is usually required.

Usual Adult Dose for Osteomyelitis:

1 to 2 g every 6 to 8 hours
Maximum dose: 12 g/day
Duration: 4 to 6 weeks, depending on the nature and severity of the infection. Chronic osteomyelitis may require additional oral antibiotic therapy, possibly for up to 6 months.

Usual Adult Dose for Peritonitis:

1 to 2 g IV every 6 to 8 hours
Maximum dose: 12 g/day

Empiric therapy of CAPD-associated peritonitis: 1 g/2 L exchange plus ceftazidime 1 g/2 L per day intraperitoneally

Maintenance therapy of CAPD-associated peritonitis: 1 g/2 L exchange intraperitoneally as a loading dose, followed by 250 mg/2 L exchange continuously
Doses should be increased by 25% to 30% for nonanuric patients.

Duration: 10 to 14 days

Usual Adult Dose for Pneumonia:

500 mg to 1 g IV every 6 to 8 hours
Maximum dose: 12 g/day
Duration: 7 days for pneumococcal pneumonia and up to 21 days for pneumonia due to other infecting organisms. The actual duration depends on the nature and severity of the infection.

Usual Adult Dose for Prevention of Perinatal Group B Streptococcal Disease:

As an alternative to parenteral penicillin or ampicillin: 2 g IV once, followed by 1 g every 8 hours until delivery

Usual Adult Dose for Pyelonephritis:

1 to 2 g IV every 8 hours for 14 days, depending on the nature and severity of the infection
Maximum dose: 12 g/day

Usual Adult Dose for Septicemia:

1 to 2 g every 6 to 8 hours for 14 days, depending on the nature and severity of the infection
Maximum dose: 12 g/day

Usual Adult Dose for Skin or Soft Tissue Infection:

500 mg to 2 g IV every 6 to 8 hours
Maximum dose: 12 g/day
Duration: 7 to 10 days, or for 3 days after the acute inflammation disappears, depending on the nature and severity of the infection. For more severe infections, such as diabetic soft tissue infections, 14 to 21 days of therapy may be required.

Usual Adult Dose for Surgical Prophylaxis:

Preoperative: 1 g IV or IM to 2 g IV 30 to 60 minutes prior to the start of surgery (or after the umbilical cord is clamped, if used for Cesarean section)
Intraoperative: 500 mg to 1 g IV or IM during surgery, for procedures lasting longer than 2 hours
Postoperative: 500 mg to 1 g IV or IM every 6 to 8 hours for 24 hours (3 to 5 days in high risk)

Usual Adult Dose for Urinary Tract Infection:

1 g IV every 12 hours for 14 days, depending on the nature and severity of the infection

Usual Pediatric Dose for Bacterial Infection:

Neonate:
Postnatal age of 7 days or less: 20 mg/kg every 12 hours

Postnatal age of 8 days or older:
2000 g or less: 20 mg/kg every 12 hours
2001 g or more: 20 mg/kg every 8 hours

1 month or older: 6.25 to 25 mg/kg every 6 to 8 hours (25 to 100 mg/kg/day)
Maximum dose: 6 g/day

SOURCE:

https://www.drugs.com/mtm/cefazolin.html

Take care.-

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