... VERY different in many unpleasant ways. Is anyone else having these problems? The generic I have used is made by Breckenridge Pharma - maybe other ones are better?
Hello khollander. Not unusual. Many users of the various drug families going from non generic to a generic brand find that given any drug in question, respond accordingly. The color of the pill/capsule, is one example. The addition of one ingredient, say a 1/2% more or less, is enough for the person taking the particular drug, to have a negative reaction. Some people do well on generics, others do not. Regards pledge
I am having the same problems after my health care provider (BC/BS) automatically switched me to the generic after 15 years of relief with Maxalt. I find that I get super dizzy and feel mentally muddled about an hour after taking the pill. I must sit down for at least 2 hours. Forget about driving or even walking. This never happened with Maxalt, so I didn't relate it to the new pill until the third time I took it. I've tried breaking it in half, which prevents the dizziness but doesn't get rid of the headache. I'm getting ready to ask my doctor to go back to Maxalt, but it's lots more expensive so I'm not sure if insurance will cover it. I'd love to hear other experiences or solutions.
Yes, this is a very unsuitable replacement, in many ways. It burns when I put it under my tongue; it is salty; it is grainy; it doesn't fully dissolve, instead it just sits there in a nasty burning lump under the tongue; the pill is much thicker than Maxalt; the packaging is a pain to open when you are having a migraine. I asked my pharmacy to find a different provider. I now use Glenmark Generics Inc. Theirs is marginally better. All of these are manufactured in India. I don't know if there is any quality control testing at all, but it doesn't appear so. Very disappointing after having Maxalt, which always worked for me. I had to really think about whether curing my migraine was worth the yuk factor of taking Breckenridge's rizatriptan.
I am also having trouble with the generics. My first replacement was manufacturerd by Breck. While packaged individually. They melted in the blister also the backing is too thick (after removing the peel off paper backing) to pop one through the blister without destroying the tablet. I next tried one from mylan mfg which were not individually packaged and do not melt. Technically it was chewable and took MUCH longer to work. I got a list of manufacturers and will try them all to find out which one works best. These are the rest of the manufacturers my pharmacy could find:aurobindo, par, sandoz, apotex, and glenmark. Please reply if you tried from any of these manufacturers. There's got to be one that is closest to maxalt in packaging. Thank you all for your input.
The first time I filled a prescription for Rizatriptan, I got the generic from Aurobindo Pharma. The first time I tried it, I told everyone that I loved this medication so much I wanted to marry it. The little tablets dissolved quickly, and the flavor was mostly minty with just a hint of icky medicine. Not unpleasant at all. My only complaint was that the packaging was a bi*** to open, but once I got to the pill, I loved it.
The next time I filled it, I got Glenmark Generics. What a horrible change! The pills don't dissolve completely, they taste HORRIBLE(not good when your migraine makes you want to puke), and I just did not get the same level of relief as I did from the Aurobindo pills. Glenmark is definitely not a win.
When I first switched from Maxalt ODT to Rizatriptan generic I used the ones made by PAR. They were nearly identical to Maxalt, including how well they worked and packaging. Then PAR wasn't available for a while a couple of years ago, and I tried Glenmark. However, they did not get rid of the migraine, and luckily PAR became available again. However, now it seems PAR has permanently quit making the medication. My last couple of refills have been Sandoz, which takes minutes to dissolve, so I end up partially chewing them and waiting for the smaller grainy pieces to dissolve. Chewing gets some stuck to my teeth, so have to get that off and rinse mouth with water and swallow several times. A pain, but at least it relieves symptoms. Now my mail order pharmacy (mandated by work to get cheaper copay) tells me Sandoz is not available. So far this is the only comparison I can find, and from the limited feedback it seems Aurobindo would be a better choice than Breckinridge. Any updated feedback from previous or new posters?
I also was switched to AUROBINDO about a year ago. I have to cut them open if I'm lucky enough to be at home but if I'm out I have to ask for assistance as I cannot open the those little pouches! At first I was putting them under my tongue and then when I started to experience feelings of dizziness and just "oddness" I pulled out the literature to look up side effects and noticed that these pills go on top of the tongue. It probably makes no difference but I now put them on top and have a warm drink to hasten melting because of the yucky taste and then have a tic tac or mint. I guess I hadn't connected this weird feeling that is similar to being "drugged" to the generic of Maxalt. I surely did not get it with Maxalt. I will bring this up with my neurologist next month. Thanks for your participation, all of you.
I thought I posted earlier to this topic, but evidently I didn't hit the "post" button... I am having a major problem with generics. I have taken Maxalt-MLT or generics for the past 10 or so years. Lately, of course, the generics, because of insurance coverage. They aren't gonna pay for the Maxalt when they have so many generics. My last prescription was from BRECKENRIDGE. This was by mistake, because I have specified to my pharmacist that I only want MYLAN generic for the rizatriptan. The Breckenridge tabs do not dissolve evenly, they are salty and bitter-tasting to me, and they just don't work! I have had migraines this month that just weren't cured because of this. My sweet hubby went all the way across town at 3am to fill my prescription and got the real deal, Maxalt-MLT because there wasn't a pharmacy around that was going to be able to fill it with the MYLAN until 5 days from now.
About 1 1/2 hours after taking 1 Maxalt-MLT tab, my 2 1/2 day migraine faded away into a pain-free bliss. Only people who get migraine headaches will know what I mean when I say this. It is so wonderful when that pain leaves your body. It is very frustrating to have a whole prescription of USELESS pills that you paid good money for.. (or your insurance company did!) I have an appointment with my doctor on Wednesday, and I am going to have a conversation with her about this issue. I cannot be the only person who has had this difficulty with this particular generic drug.
I am in precisely the same situation. For years brand name Maxalt was a perfect treatment for my migraines; this was true whether I took the standard pill form or the orally disentegrating version. At some point several years ago, my prescriptions started being filled by a generic orally disintegrating version of rizatriptan. And in general, I found little difference. They melted similarly, seemed to be just as effective and did not seem to spur any new side effects over the brand name.
That changed in the last year or so, when the generic version being dispensed by my pharmacy shifted to a version that doesn't melt and disappear in the mouth and instead is one that remains grainy. I don't really care much about that (though it is unpleasant). Unfortunately, though, this new generic version -- the one made by Breckenridge -- seems to induce incredible sleepiness and dizziness in me. Now, when I have a migraine and am desperate for relief, I weigh the opportunity cost of two days of lethargy and extreme drowsiness against the pain relief.
I have never encountered any noticeable, substantive difference between a generic and brand name of a drug before. This is a dramatic difference, and it's awful.
In case it helps anyone else, there's a pretty big difference in the inactive ingredients for the Breckenridge version of the orally disintegrating rizatriptan and the brand name Maxalt version. For the Breckenridge version, those inactive ingredients are listed as: aspartame, croscarmellose sodium, crospovidone, glycine, magnesium stearate, mannitol, microcrystalline cellulose, monosodium citrate anhydrous, peppermint flavor and sodium chloride. For Maxalt, those inactive ingredients are listed as: gelatin, mannitol, glycine, aspartame and peppermint flavor.
I get my prescription filled at CVS, and my local CVS pharmacist just told me all he has is Breckenridge's generic; no other generic rizatriptan is available, at least to him. Has anyone had luck getting a different generic, made by a different manufacturer? What pharmacy do you use?
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