I have been on lamotragin for over five weeks time and am now at 100 mg for one week with no effect. I'm scared. Could this medicine still work? When I went to 50 I had 8 days of heaven... it worked, but then woke up the next day and it was gone. Does anyone have a remotely similar experience or suggestions? I am recently designated soft bipolar due, in part, to the fact the effexor I used for 8 years (37.5) stopped working and when we slowly went up to 150 I got even worse (anxiety and depression). I now take 75 mg effexor woth the100 mg lamotragine. Thank you for reading this everyone. God bless.