... ups. It helps tremendously to reduce inflammation, reduce pain, and is very effective. Last week when I went to my doctor the nurse came in with a syringe that did not appear to be what I usually take. I asked her about it and she said it was the same I always took. I asked her what it was and she said it was dexamethasone 10 mg IM, and swiftly injected me before I could express my concerns. I told her that for years I had taken depomedrol 80 mg IM. On the way home, after a period of euphoria, the pain increased and I have been in severe pain ever since. Has anyone been treated with dexamethasone 10 mg IM for the excruciating pain I have with my connective tissue, degenerative disc disease, and degenerative arthritis of the spine? Or any other chronic severe pain? Any info would be helpful and appreciated