Perhaps the drug needs more time to kick in. However, that would be contrary to my experience with every other helpful anti-depressant I have taken the last 18 years. With those drugs (trycyclics, cymbata, zoloft, etc), the impact was almost immediate. Just one dose would make me feel substantially better. So far, with viibryd I feel substantially worse since I went off zoloft and began taking viibryd. Zoloft worked reasonably well for me, but my doctor recommended viibryd because it apparently does more than a typical SSRI, which inhibit the re-uptake of serotonin. Viibrd does the same, but supposely it can also increase the amount of sertonin the brain/neurons produce. I am extremely disappointed with viibryd. Any suggestions?