Sally I have taken both and not really had side effects outside of the zantac does not last as long if you really have stomach problems where protonex is more of a timed release and stays in your system longer both also have a healing effect have you had your stomach checked to see if its a ulcer or just bad Gas..Anyway my personal vote for me is protonox i take one ever day in the morning have no side effects and rarely have stomach problems anymore. they both by the way come from the same or very close family of drugs so you should not have problems if you can take one or the other... IF it continues see your doctor and find out what is going on... Chuck1957
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