I have been on 50mg Seroquel for over a year. It use to work great and I was asleep within 30 minutes and woke up non groggy and alert. Now I'm wondering if I am use to it because for the past couple of weeks I can't fall asleep. Please help anyone else have this issue? Should I ask my doctor to increase the dose? It had been the only thing that helped me sleep and helped anxiety and depression!