I completed 4 weeks of rituxan treatments and my platelet count increased from 40 to 81. Now a month later, they've crashed to 40 again and my white and red blood counts are also low. I'm worse off than when before I started treatment. Has this happened to anyone? Is it typical to have such wild fluctuations? How long does it take to work? I have systemic Lupus, which probably accounts for the low platelet count. My doctor said I could also be going through a Lupus flare because my hair has started shedding again at a rate before I was diagnosed with Lupus. My doctor has no answer whatsoever.