No one can equate the amount of appetite that topamax will suppress vs. the amount of hunger remeron might cause. It would be great if they cancel out or you still have reduced appetite. The daily limit for topamax is 400 mg but I don't know if that is given for appetite suppression. I take 300 mg per day for appetite supression. It comes down to how these drugs affect you in your body because we're all different. I hope you can get back into your weight training and the kickboxing and so forth. I hope I said the right things that you like to do. Those are great activities to be doing. Don't be surprised if your antidepressant takes away your endorphin "high" from your workouts. Sometimes it just does.