Question about methadone? If I took 30mg of methadone 13 hours ago. Is it safe to take 30-40 mg of hydrocodone (Lortab) now? I do have high tolerance for hydrocodone - normally take 150mg per day and have for the past year. I do not have an established tolerance for methadone though and have only taken it 2 days without taking any hydro. I know the methadone stays in your system longer so don't know if 13 hours is long enough and safe enough to wait to take hydro now. Any help would be greatly appreciated!!