My doctor said that my body metabolizes this medication quickly. But he still wants me to try 25 mg of Zoloft, so he says I shouldn't have any side effects. I recently lost my mother and found out my husband was having an affair. So I really need something to help me, I'm on Xanax and he also prescribed Zoloft just don't know if I should even try it if my body is going to kick it out quickly. Can anyone relate??