The abbreviation is used in conjunction with excessive or prolonged CNS in describing interaction with diphenhydramine.
Copied from drugs(dot)com:
Nervous system side effects have been reported frequently. These have included depression with drowsiness and sedation in nearly all patients treated. Motor skills may be impaired. Dystonic reactions have been reported after single doses of diphenhydramine.
The CNS depressant effect of diphenhydramine parallels its plasma concentrations. The plasma concentration threshold for sedation is 30 to 42 ng/mL, and to cause mental impairment is 58 to 74 ng/mL. Patients should be warned against driving while taking diphenhydramine.
Dystonic reactions have been accompanied by dizziness, mental confusion, rigidity, lip and tongue protrusion, trismus, torticollis, and swallowing difficulties and generally resolve spontaneously. Toxic encephalopathy has been reported in a child with chicken pox treated generously with topical diphenhydramine.
Delirium has been reported in elderly patients with mild dementia following a small oral dose of diphenhydramine.
Hope this helps with what you're looking for, but like the other respondents, I'd need more data to start with.
- Diphenhydramine Information for Consumers
- Diphenhydramine Information for Healthcare Professionals (includes dosage details)
- Side Effects of Diphenhydramine (detailed)
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