I have taken Phentermine on and off for years. The appetite suppressant effect isn't working. I started Qsymia 2 days ago to see if the Topomax part would help. Thus far, the only effect I feel is being tired from the decreased amount of Phentermine. I contemplated trying HCG injections but after reading the potential risk,I chose to try Qsymia. Any comments from experience about the appetite component of qsymia and how long to expect it to take to "kick in" if you will is much appreciated. I'm impressed at all the successes on this site. Thanks in advance to you all!