Have had PA for 11 years and generally well managed thru anti-inflams and... metheltrexate. Did have a heart attack 2 1/2 years ago and a stent. This fall / winter / spring have had on-going sinus infections / colds with only about 10 weeks well of 7 months. Ugh! Anyone else had this experience unable to clear sinus infections despite 4 bouts anti-biotics. My cold symptoms are heavy sinus discharge in nose, sore throat, coughing, head ache occasionally, squeeky voice, fatigue.