She just changed medication she is taking Prozac 20 mg per day and it's been a week since she started, and this isn't working at all.
Your wife is doing that because she is depressed. Do you not think that given a moment she would tell you she is is in this personal hell and that if she could just wish it away she would? Sadly one week on an anti depressant isn't indicative of anything; you will have to wait longer than that to see if it is beneficial. I recommend you do some reading about depression so you can be supportive.
The feeling sorry for herself phrase didn't help much. Many of us here suffer from depression. None of us want to feel sorry for ourselves but as stephen says its our own personal hell. I call it the black hole. Did she taper off the other medication before she started the prozac and what was it? It takes 4-6 weeks for the prozac to start working. As stephen says you need to be supportive. I have 2 ex husbands because they had your attitude.
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