Have been on Zoloft and Cymbalta and they are great for my depression and anxiety, although I thought Cymbalta was better once I got over the nausea and accepted that a weight gain of 20kg I could live with. But the joint and muscle pain was debilitating. One day it was so bad I could not pick up a mug of coffee. My Doc has suggested Prozac, I am really hoping for a good outcome. Sue