I have been on Prozac for just about two months, and it's been wonderful. I feel better than I have in YEARS, and I thought I was going to be ok after all. Last week, I had a sinus infection which turned into bronchitis. I was put on Prednisone and Zithromax and ever since, I've been an angry, iritable mess. It's been 7 days, and I'm miserable. I go to work and rage all day, then come home and just want to go to bed. It's like the Prozac isn't doing anything anymore. Is it an interaction? Or is the initial kick of the Prozac wearing off?