My mother's PCP prescribed Omeprazole 20 mg 2 X a day. My impression was that this medication should be taken only once in a 24 hr period. She is 92 yrs old, weighs 108 pounds and is taking this for probable acid reflux that was possibly causing a chronic cough. Her medicare part D will only allow payment for once a day dosing making me think her prescription dose is not correct. Is there really any benefit for taking this twice a day instead of once a day? Could there be any potential side effects with taking this BID (especially on a long term basis)? She is also taking digoxin and warfarin - both listed as possible problems with this drug.