... anyone else using the suppositories found that it causes diarrhea. I use 25mg to 50mg of this medication every 4-6 hrs, on a bad day
I use Promethazine tablet form and suppositories because I am nauseated most of the time, does?
- Asked
- 7 Apr 2012 by ukliz
- Updated
- 1 Jul 2012
- Topics
- promethazine
Responses (2)
Hi Liz, & Happy Easter! I just looked up this med & didn't see anything about diarrhea, but everyone is different. In fact it says it can cause constipation. Go figure! I think that was for an oral type altho'. I will give you the link I used & maybe you can research the side effects more. Could it be interreacting with one of your other meds? The link will give you an idea on those too. Have a great Easter & write me now & again if you feel up to it! Love, Mary
https://www.drugs.com/promethazine.html
I use the 25mg suppository when I get migraines (in addition to a migraine drug). I have used the suppositories under several different circumstances, however, and each time I have had diarrhea. So, you are not alone! Usually it is within 20 minutes of insertion (tmi? Sorry!) I didn't think they could absorb that fast, but they haven't failed me yet. It is the only thing that can keep me from tossing my cookies with a migraine. Worth a couple minutes ON the toilet versus hours with my head hanging over it!
Thanks for answering, and your right in saying about spending a few minutes on the toilet verses hours trying to throw up. Take care, Liz.

Further Information
- Promethazine Information for Consumers
- Promethazine Information for Healthcare Professionals (includes dosage details)
- Side Effects of Promethazine (detailed)
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Happy Easter to you too, and to everyone else on the DC site. I don't get the diarrhea when I use the tablet form, I slept through the night so I don't feel to bad today, I will write to you later. Love Liz.