I was told that it is the major or one of the major contributors that can lead to renal failure.
Renal failure can happen with Procardia XL (nifedipine) but it is very uncommon.
Renal side effects have included kidney calculus (less than 1%) and new or worsened renal insufficiency (less than 0.5%). Patients who are at higher risk include the elderly and patients with preexisting renal or arteriosclerotic vascular disease. Use of nifedipine has also been associated with improved glomerular filtration rate and effective renal plasma flow in hypertensive patients with moderate renal dysfunction, regardless of its antihypertensive effect.
Rare cases of immune-complex nephritis and nephrotic syndrome associated with nifedipine therapy have been reported. A case of acute, reversible renal failure attributable to nifedipine administration in a patient with congestive heart failure has been reported.
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