Just started Pristiq on Saturday. Day 1 I felt numb. I have no voices in my head and no emotion. Not a feeling I enjoyed but because I am so tired of feeling sad or anxious it was like a little mini vacation. Now it is day 3 and I feel incredibly low again. I am just on a starting dose, 25mg and next week going up to 50mg. If Pristiq is going to make me feel numb with no emotions I am not sure it is worth it. It is incredibly discouraging. I got genesight testing done to find out what meds would work and which ones would not. This was one that was supposed to work, and it is day 3 and I am already feeling worse then I was when I started. Not sure if it is worth it or if any medication is worth it. This was my last resort.