I came off pristiq due to massive weight gain from the drug over a 6 month period. About 25lbs. I've now been drug free for 3 months and weight exactly what I did the day I came off it. I train watch what I eat. I barely ate for two weeks straight and lost about 4lbs. We had friends over on Sunday night I had steak three glasses of champagne and a chocolate brownie and put back the 4lbs. This is after training very intensely for over an hour earlier in the day. Has anyone else had this problem with pristiq. Help! I'm losing my mind here!