... after many failed attempts at different medication he has finally found one that works for him; pristiq, he is prescribed 100mg a day. He now has absolutely no interest or desire to have sex like he once did and it is putting serious strain on our relationship. He's afraid that if he changes meds again this will have an extremely detrimental affect on his mental health and clearly that must come first, all I'm asking is if anyone else has had a similar experience and perhaps has some advice on how to overcome this issue, if that is a possibility. Any advice from anyone would be greatly appreciated :)