I have read so many reviews on pristiq and many people reported that they felt an immediate lift in their moods within few days of taking it. I have been taking pristiq 50 mg for almost 4 weeks and I have not noticed any improvements in my depressive symptoms. I understand these medications affect people differently but it dawned on me that people who take pristiq seem to achieve faster relief than any other medication. I guess this is just a mystery of human physiology. And treating depression takes a lot more than just inhibiting reuptake of couple of transmitters. It is actually a very complex process. So I don't understand how some people achieve positive results so soon into their treatment. And I'm beginning to think I need to have my brain dissected.