I currently take 50 mg of pristiq and 50 mg of seroquel xr both in the a.m. My psychiatrist just gave me the option to increase both my prescriptions because I am really battling with depression, anxiety, and a mood disorder. She said it was up to me which one I wanted to increase (im not going to increase them both at the same time that way I know which one is helping.) I guess I have two questions: for those who take one or both of these medications... if you take 100 mg of pristiq do you take it all at once or 50 mg twice daily? Same with the seroquel xr... have you taking found 100 mg xr works better for your mood and anxiety, or 50 twice a day? I also would like any opinions on which one I should try increasing first. Thanks in advance.