... pristiq 50 mg for 2 years and that has helped with depression. In the past 2 months I have gone up to pristiq 100mg because I was accustomed to the other amount. I also have severe anxiety and take clonazepam .5mg 4 times. I have gotten better. Less depression and anxiety and worry, less paranoid, but has not had the effect that it should, my fiancé says I still seem down and that I'm not completely myself but better. I have been prescribed abilify 2mg to take with the other ones so I was wondering if that will have a difference? Is it common to feel drowsy and tired, and a little more depressed and anxious the first few days of taking the new pill that was added? Is it just going to take a little time for it to kick in? Thanks