I take my Prempro in the morning & I'm so sleepy til the afternoon, how long does the tiredness last? I tried taking it at night but I'd still have the hot flashes, mood swings, insecurities all the next day. What should I do? When I take them in the am I actually get horny right away or sometime during that day & for 5 years before I started prempro I couldn't have sex with my husband it made me nauseous even thinking about sex.