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Pregnancy - I'm amost 3 months pregnant, can I take Nitrofurantoin mono-mcr for an urine infection?

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Marvell 23 Dec 2011

You will need to discuss the benefits and risks of using Nitrofurantoin while you are pregnant. Do NOT take Nitrofurantoin if you are at term (38 to 42 weeks pregnant), if you are about to go into labor, or if you are in labor. Nitrofurantoin is found in breast milk. Do not breast-feed infants younger than 1 month old while you are taking Nitrofurantoin. If your child is older than 1 month, check with your doctor. Discuss any possible risks to your baby.

Nitrofurantoin Pregnancy Warnings

Nitrofurantoin has been assigned to pregnancy category B by the FDA. Animal studies have failed to reveal evidence of fetotoxicity or teratogenicity except when administered in very high doses. While there are no controlled data in human pregnancies, nitrofurantoin-induced congenital anomalies have not been reported to date. Nitrofurantoin should only be given during pregnancy when need has been clearly established. The use of nitrofurantoin is contraindicated near term (38 to 42 weeks gestation) and during labor and delivery because of the potential for induction of hemolytic anemia in the neonate due to low levels of red cell glutathione in this population.

One retrospective review of 91 pregnancies involving nitrofurantoin use reported no evidence of association to fetal adverse effects. In a review of 229,101 deliveries to Michigan Medicaid patients, there were 1292 first-trimester exposures to nitrofurantoin and 9998 exposures anytime during pregnancy. A total of 52 birth defects (55 expected) was reported with first-trimester exposure and included (observed/expected) 15/12 cardiovascular defects, 1/0 oral clefts, 4/3 polydactyly, 3/2 limb reductions, and 5/3 hypospadias.

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