The FDA uses a pregnancy category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy. Pregnancy Category B is given to medicines that have not been adequately studied in pregnant humans but do not appear to cause harm to the fetus in animal studies.
When large doses of amoxicillin were given to pregnant rats and mice, the medication did not cause any problems. Studies have shown that amoxicillin crosses the placenta (to the baby) in humans, but it does not appear to cause problems. Although amoxicillin has not been systematically and adequately studied in pregnant women, case reports and surveys seem to suggest that amoxicillin does not increase the risk of birth defects or miscarriages.
However, since amoxicillin has not been adequately studied in pregnant women, it is possible that it may have negative effects that are not currently known. Therefore, a pregnancy Category B medicine should be given to a pregnant woman only if a doc believes that the benefits to the pregnant woman outweigh any possible risks to the unborn child.
Take care, please consult your doc/pharmacist, best wishes!
Many women have taken it during pregnancy, but the doctors will have to consider risks verses benefits.
This the advise given
Amoxicillin Pregnancy Warnings
Amoxicillin has been assigned to pregnancy category B by the FDA. Animal studies using 10 times the human dose have failed to reveal any evidence of teratogenicity. Although no controlled data in human pregnancy are available, literature reports of adverse fetal effects are lacking. Amoxicillin is only recommended during pregnancy when benefit outweighs risk.
In the Collaborative Perinatal Project involving 50,282 mother-child pairs, there were 3,546 mother-child pairs exposed to penicillin derivatives in the first trimester. As a group, there was no significant increase in the risk of malformations. In the Michigan Medicaid Birth Defects Study involving 229,101 pregnancies from 1985 to 1992, there were 8,538 first trimester exposures to amoxicillin. Overall, 317 cases of birth defects were observed (363 expected). There was no evidence of an association between first trimester use of amoxicillin and major groups of malformations. A Danish study of 401 women exposed to amoxicillin during pregnancy from 1991 to 2000 did not find an increased risk of birth defects or adverse outcomes compared to women who had taken no medication. Transient decreases in total conjugated estriol, estriol-glucuronide, conjugated estrone, and estradiol plasma concentrations have been reported in pregnant women who received ampicillin and this may also occur with amoxicillin.
Amoxicillin has been assigned to pregnancy category B by the FDA. Animal studies using 10 times the human dose have failed to reveal any evidence of teratogenicity. Although no controlled data in human pregnancy are available, literature reports of adverse fetal effects are lacking. Amoxicillin is only recommended during pregnancy when benefit outweighs risk
Search for questions
Still looking for answers? Try searching for what you seek or ask your own question.
Posted 27 Jul 2013 • 1 answer
Posted 22 Jun 2014 • 1 answer
Posted 14 Aug 2015 • 0 answers
Posted 10 Nov 2015 • 0 answers
Posted 1 Apr 2016 • 0 answers