How much of the drug is excreted, and how much is left within the system??
Pregabalin (Lyrica) is one of those weird medications that we don't fully understand and know a great deal about. Some argue that it's mechanism of action for nerve pain, anxiolysis (anxiety reduction) and sedation is due to stimulation or modulation of the GABA system. Where others argue that it solely acts by binding to calcium channels. Pharmacodynamically, we're a bit perplexed.
As for pharmacokinetics, which is what you asked about, pregabalin is not highly metabolised. It is metabolized by methylation in very small amounts. But overall, its similar to metformin in the sense that it is merely absorbed by the stomach into the blood, circulates around the body, however with a small volume of distribution (meaning that it doesn't spread extensively into the body's tissues), and is excreted by the kidneys (mostly unchanged) by first order kinetics. It has a biological half life of about 7 hours, meaning that after about 28 hours, almost all of a 'normal' dose of ingested pregabalin will be gone from your body.
Hopefully that answers your question.
- Pregabalin Information for Consumers
- Pregabalin Information for Healthcare Professionals (includes dosage details)
- Side Effects of Pregabalin (detailed)
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