Have been taking increasing doses of prednisone 10 to 20 mg/day for control of back joint pain. I have found that on the occasions when I have needed a medrol pack my pain is gone for several days. It is my understanding that prednisone is converted to the usable Methylprednisilone by the liver. Is it possible that my liver is not converting, or at least not well, that transformation to methylprednisilone. I am considering trying the converted potency dose to methylpred to see if that works better and maybe be able to reduce (over time) the overall dose.