I take the 60 mg at once, I also take Alendronate 5mg/daily and losartan 100mg/day and vitamin D, calcium, and fish oils. 3 weeks in and the effects are brutal. My sleep pattern is awful- I find it very difficult to fall asleep and stay asleep. My eyes are puffy and there is pressure. Occasional dizziness. I have a lot of difficulty focussing, pins and needles in my hands and feet, extremely thirsty, burning sensation in my hands and feet, irritability, low to non existent sex drive, mood swings and in the last couple of days a red, blotchy, sometimes itchy rash on my chest, neck, back and face. Is this all normal to Prednisone use? Do the side effects ease? Anyone else on here with a similar condition?