... COLISTIN SODIUM IV COLYMYCIN-M POLYMYXIN-B. Unfortunately this is not available there and the patient is drug-resistant to other antibiotics. Thier physician said that this is only available in Singapore. Does anybody knows where we can purchased /ordered this medicine? The patient is at Lung Center Hospital in Manila Philippines
This link from the national institute of health may help...
"Colstin is available commercially in two different formulations. Colomycin (Dumex-Alpharma, Denmark) has half million, 1 million or 2 million IU per vial i.e., about 12,500 units/mg whereas Coly--Mycin M parenteral (Parkedale Pharmaceuticals, USA) contains 150 mg colistin base activity. The recommended dosing schedule varies as per the manufacturer. Colomycin manufacturers recommend 50,000 to 75,000 IU/kg/day (4–6 mg/kg/day of colistin) in three divided doses. On the other hand, Coly--Mycin manufacturers recommend a dose of 2.5 to 5 mg/kg colistin base activity per day in two to four divided doses (6.67-13.3 mg/kg/day of CMS). Various studies support an acceptable safe dose of 6–9 mg/kg/day of Colomycin and 2.5–5 mg/kg/day (6.67-13.3 mg/kg/day) with Coly--Mycin. So there is a possibility of under-dosing with colomycin if it is administered in the recommended doses of manufacturers. Colistin is available in India as Xylistin (Cipla Pharmaceuticals), containing half million or 1 million units per vial and the dose followed is 50,000 to 75,000 IU/kg/day."
- Polymyxin B Information for Consumers
- Polymyxin B Information for Healthcare Professionals (includes dosage details)
- Side Effects of Polymyxin B (detailed)
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