PV dx'ed 2009, 54 yr old female, only meds are 81mg aspirin and stomach pill. Hem said in Jan.2013 he can feel the tip of my spleen. He said try JAK2 drugs in the near future. Symptoms from PV started in 2005, but dx'ed in 2009.
There are different classifications of your condition, which still today can be confusing despite the World Health Organisation attempts to classify it. With some types of Polycythaemia Rubra Vera (That’s what I know your condition as) Splenomegaly (enlarged spleen) is not uncommon. Usually the Patient would have a CT, MRI or ultra sound scan to determine the size of the spleen. This maybe done closer to a change or addiction in treatment. Patients at low risk of thrombosis and thrombotic events such as heart attack and stroke, are treated with aspirin (which delays clotting time) and phlebotomy (To draw blood from a patient). Janus kinase inhibitors also known as JAK inhibitors are a type of medication that functions by inhibiting the activity of one or more of the Janus kinase family of enzymes. The aim of JAK2 inhibitor is a reduction of spleen size. These drugs are relatively new so on this matter I will refer your case to a couple of DC members to see if they can help.
JAK2 enzyme. While they may prove to be effective in controlling hyperproliferation of hematopoietic cells in PV and ET, they may not be able to eliminate mutant clones. On the other hand, JAK inhibitors may have great therapeutic benefit by controlling the disease for patients with MPNs who suffer from debilitating signs (eg, splenomegaly) or constitutional symptoms (which presumably result from high levels THIS IS A COPY PASTE Maky59 this and several other types are back out and different ones it is also works on different types of cancer do not get alarmed this reduces the swelling in the spline by shrinking it and the blood and also disolves any clots sometimes dr may keep you on the low dose aspirin.It was taken off the market for a while for other reasons then what they are using it on you and they got those bugs nocked out of it aka side effects I would if it were me feel well about taking this and the doctor well keep a close eye on you and your spleen to reduce the swelling which is more comman than you may think... hope this helps some for you now its to ruduse the size of spleen many reasons virus infections and to much blood gets into the spleen and this is the one they use and it sounds like they have another they are working on but has not been approved..i beliver what you have is the splenomegaly okay hope this helps any questions i can help i friended you and you can reach me direct im still confused how all this works in here have a great day.and life my new friend
Charles Wise Sr. Retired Pharmacy techienician Cpht Oregon...
- Aspirin Information for Consumers
- Aspirin Information for Healthcare Professionals (includes dosage details)
- Side Effects of Aspirin (detailed)
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