I've been on Plaquenil for almost 4 mo. and no significant change yet. A little less fatigue but still have pain most of the time especially neck and shoulders, low back and hips. Also taking Naprosin and due to increase in GI irritation tried to wean myself off but discomfort much worse leading me to believe Plaquenil not doing much at all. Was told it could take 4 mo but doubt that on the first day of the 5 th mo change will occur. When should I start seeing some effects if in fact it is going to help?