... different effect
Could the same medication and dosage from 2 different manufactureres have slightly?
Added 5 Jul 2009:
When I received a refill, they also broke apart more easily. Is this significant. I need about 1/2 my usual dose for the same effect. I'm not complaining...they'll last longer. But I've taken this medication for several years, have had maufacturer changes before but never found there to be a difference in effectiveness.
The short answer is absolutely.
Once a patent on a drug runs out, the drug can start to be produced by other companies and sold as "generic". The generic forms are most often cheaper than the name brand drug, and therefore are attractive to insurance companies who wish to keep costs low. The company that is producing the generic form will often compound the active drug with their own "proprietary" binders and fillers. The activity of the drug can be altered because of this. However, the activity is tested in focus studies and in lab animals before the drug is released for human use to ensure that it still works. An example of this is that, personally, whatever is compounded in name brand Vicodin gives me nausea, however generic forms of Hydrocodone do not. Hope that helps!
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