Do different manufacturers use different ingredients in the dtug phenytoin. I am having very different side effects being on same drug but different manufacturer. Currently on phenytoin and had little to no side effects (manufacturer-Ameal) pharmacists recently gave same phenytoin diff color (manufacturer-Sun Pharmaceuticals) stronger seizure, anexity, slight numbness and or tiggling in arms legs hands feet.. what the heck is going on? (Bio- 32f. Started seizures 4yrs ago first was grand mal after been partial complex. 2 kids before and 2 kids since. Low iron Vit D diffency)
The phenytoin is the same, but they can have different inactive ingredients and this effects the absorption of the drug. You may need it increased while you have these pills. I would report it to the FDA, what happened for you. If they get enough complaints they investigate the company. Are you taking vit D? Its important that you do, it makes you loose D and that can cause things like your gums swelling. Be sure you tell your pharmacy about it.
There are a few drugs that they say to stick with the same manufacturer always (or as much as possible) and Phenytoin is one of them. There can be differences in binders and inactive ingredients and these can affect absorption. With a drug like phenytoin, it is critical that your blood levels remain steady. One thing that has worked for my patients in the past is for your Dr to write a letter to your pharmacy asking them to keep in stock one manufacturer (or the brand name if your health plan lets you have it) for you. If the pharmacy you use is one that tends to use different manufacturers all the time then you might try switching pharmacies. Pharmacists KNOW that patients on phenytoin should stick to one manufacturer's drug as consistently as possible but yet some pharmacy suppliers are really bad about constantly changing manufacturers to get the best prices, especially deep discount pharmacies because that is how they bargain for low prices. For patients on phenytoin this is not a good thing. If you start on brand name Dilantin, you should stay on the brand name. If you have to use generics, you should try to stick with the same manufacturer at all times possible. Many of the larger chain pharmacies and often the "mom and pop" pharmacies tend to stick more consistently with one manufacturer when it is available
- Phenytoin Information for Consumers
- Phenytoin Information for Healthcare Professionals (includes dosage details)
- Side Effects of Phenytoin (detailed)
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