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What is the ph,pka and solubility of dexlansoprazole ?

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vijay4151 13 Aug 2012

Dexlansoprazole is a proton pump inhibitor which is used as an untiulcer drug in the treatment and maintenance of healing of duodenal or gastric ulcers, erosive and reflux esophagitis, NSAID-induced ulcer, Zollinger-Ellison syndrome, and Barrett's esophagus. Lansoprozole is active against Helicobacter pylori.

Chemically, it is an enantiomer of lansoprazole.

It suppress gastric acid secretion by specific inhibition of the (H+,K+)-ATPase enzyme system at the secretory surface of the gastric parietal cell.
Because this enzyme system is regarded as the acid (proton) pump within the parietal cell, Lansoprazole has been characterized as a gastric acid-pump inhibitor, in that it blocks the final step of acid production.

it is freely soluble in water and having the water solubility 0.97 mg/L

pH is defined by the negative logarithm of the hydrogen ion activity.

This drug was having acidic pH that is approximately 5.5

Lansoprazole is stable when exposed to light for up to two months. The rate of degradation of the compound in aqueous solution increases with decreasing pH. The degradation half-life of the drug substance in aqueous solution at 25°C is approximately 0.5 hour at pH 5.0 and approximately 18 hours at pH 7.0.

The pKa (The negative logarithm of the acid dissociation constant, Ka)of the lansoprazole is 17.3

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