... My Dad passed away 6 years ago at the age of 56 from brain cancer. Since then I also developed Major Depression. I started a new med two weeks ago... Brintellix. It made my anxiety double. So the doc also prescribed Lorazepam which is not helping. My chest constantly feels tight and my stomach is in knots. When I go out in public I feel disoriented. It's awful. Why do so many of these meds have side effects that can make everything so much worse? Has anyone tried a holistic route with success?