After a surgery the doctor would always give me a pain pill with acetaminophen with it. I would tell the doctor that they always cause Extreme itchiness! The doctor would tell me just take an antihistime This did help with the itchy but is this safe and also I know to much acetaminophen can interfere with the liver and it doesn't take much. I am also confused because liver damage also has a sign... Skin Itchiness Please help. I would like to get to the bottom of this ASAP Thanks Linda