I have MS, narcolepsy, scoliosis, separated shoulder that they can't fix due to paralysis I've been in a wheelchair for 10 years and my hips hurt, no thyroid due to radiation treatments. I am currently taking levothyroxine, hydrocodone, Lyrica, Cymbalta, and tramadol. My doctor wants to change the hydrocodone and tramadol to tapentadol and oxcarbazepine. I am afraid of serotonin syndrome due to the narcolepsy and also the interaction with the thyroid medication. Is this combination safe or am I better off to stay with a higher dose of hydrocodone? I am currently on four 10/325 Norco tablets. This is what my doctor intends on replacing and will be also replacing the tramadol.