Oxycodone is classified as FDA pregnancy risk category B. No reports of congenital defects have been reported in pregnant animals or humans, but no well-controlled studies in pregnant women have been performed. The pregnancy risk factor increases to FDA risk category D if oxycodone is used for prolonged periods during pregnancy or in high doses close to term. Neonates whose mothers have been taking oxycodone chronically may show some respiratory depression and/or withdrawal symptoms at birth or within a few days. Controlled-release oxycodone is not recommended for use in women during and immediately prior to labor and obstetric delivery because oral opiate agonists may cause respiratory depression in the newborn.
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