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Oxcarbazepine - Pharmacokinetic?

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Marvell 12 Nov 2009

Following oral administration of Oxcarbazepine tablets, Oxcarbazepine is completely absorbed and extensively metabolized to its pharmacologically active 10-monohydroxy metabolite (MHD). The half-life of the parent is about two hours, while the half-life of MHD is about nine hours, so that MHD is responsible for most antiepileptic activity.

Based on MHD concentrations, Oxcarbazepine tablets were shown to have similar bioavailability.

After single-dose administration of Oxcarbazepine tablets to healthy male volunteers under fasted conditions, the median tmax was 4.5 (range 3 to 13) hours.

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