The most visible aspect of myeloma disease is its effect on bones throughout the body.
Bone destruction by osteolytic lesions is caused by two separate events.
1. Rapid growth of myeloma cells inhibits normal bone-forming cells, damaging bone.
2.In addition, production of substances that activate the cells that resorb bone called osteoclasts is increased. Osteoclasts normally break down old or worn out bone and work with bone-forming cells to repair bone. Increased activity of osteoclasts, however, causes bone loss with concomitant loss of bone repair and growth from the suppression of bone formation.
See these links for more information
Search for questions
Still looking for answers? Try searching for what you seek or ask your own question.
Posted 12 Aug 2009 • 2 answers
Posted 4 Aug 2010 • 7 answers
Posted 6 Feb 2014 • 1 answer
Posted 8 Feb 2014 • 1 answer
Posted 3 Feb 2015 • 1 answer