Hyaluronic acid is normally present in joint fluid, and in osteoarthritis sufferers this gets thin. Hyaluronic acid can be injected into the joint, as an artificial joint fluid, to help protect it.
I suppose it is only (well mostly) injected in the knee joint because it needs the most cushioning (compared to other joints which may suffer from osteoarthritis) as it bears the most weight, so by lubricating that joint you ease the pain.
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