To be honest with you, they can be pretty uncomfortable. They use a fairly large needle that can accommodate the almost gel-like fluid directly into the knee joint. Although your first reaction after receiving the injection is to go home and move as little as possible, it's best to maintain some moderate activity as that will help disperse the fluid around the joint. I usually found that I felt pretty good by the next day as long as I didn't try and overdo things.
Best of luck with your injections!
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