oral bioavailability of rivastigmine capsule...
Rivastigmine is well absorbed with absolute bioavailability of about 40% (3-mg dose). It shows linear pharmacokinetics up to 3 mg BID but is non-linear at higher doses. Doubling the dose from 3 to 6 mg BID results in a 3-fold increase in AUC. The elimination half-life is about 1.5 hours, with most elimination as metabolites via the urine.
- Rivastigmine Information for Consumers
- Rivastigmine Information for Healthcare Professionals (includes dosage details)
- Side Effects of Rivastigmine (detailed)
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Anybody can give the few example of new drugs having low oral bioavailability due to low solubility?
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